In theory, the acknowledgment of a research within the scientific area (citation count) and how it influenced the knowledge of a disease and/or its treatment, as well as whether it brought about any new research trends, are the reflection of its quality . The authors have no conflict of interest to disclose. (1)Five-year journal impact factor: this indicator represents the citation counts received by a journal, in one year, of the citable papers published in the last 5 years. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone.During surgery, the BMP is soaked onto and binds with a collagen sponge. The key steps in this cascade are chemotaxis, mitosis, and differentiation. Sign up here as a reviewer to help fast-track new submissions. UCLA Bone Research Laboratory, Department of Surgery, School of Medicine, University of California, Los Angeles, California 90024, USA ... Journal of Dental Research ISSN: 0022-0345 Online ISSN: 1544-0591. In the present study, majority of the studies (58%) were published in high impact factor journals dedicated to dentistry, oral surgery, and medicine such as the Journal of Periodontology, Journal of Dental Research, Journal of Clinical Periodontology, and Clinical Oral Implants Research. The bone morphogenetic family and osteogenesis. Dental implants anchor the permanent prosthetic teeth to the bone. >> T1 - The application of bone morphogenetic proteins to dental tissue engineering. The differentiation of dental pulp cells (DPCs) plays an important role in the repair of dental pulp injury. Recombinant human BMP‐2 (rhBMP‐2), for example, has been shown to induce ectopic bone formation in an in vivo setting. The journals’ ranking based on their impact factor has become a principle consideration when authors decide where to submit their research. Several bibliometric studies have reported that authors hailing from institutions of Asia and Africa whether being the first or the corresponding authors made an almost negligible contribution which could be regarded as the “classic article” [76, 83, 88, 90, 91]. Second, the analysis of self-citations and citations in textbooks and lectures was not performed. Bone Morphogenetic Protein. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. This bibliometric analysis is aimed at identifying and analyzing the top 50 most-cited articles on the dental applications of BMPs. Its calculation follows the following formula: citations from journal citation report (JCR) year of documents published in the last 5 years, divided by the total number of citable documents . Bibliometric analysis is helpful to determine the most influential studies in a specific field. /ToUnicode 6 0 R The top 50 most-cited publications originated from 11 countries, including Austria, Brazil, Germany, Italy, Japan, Netherlands, South Africa, South Korea, Switzerland, the United Kingdom (UK), and the United States of America (USA) (Figure 4(a)). The sponge is then designed to resorb, or disappear, over time. BMP-2, BMP-4, and BMP-7 have been reported to stimulate in vivo, in vitro, and de novo bone formation in several animal models [13, 14, 16, 18]. Bone morphogentic protein 1. Introduction. As the sponge dissolves, the bone morphogenetic protein stimulates the cells to produce new bone. However, in the recent years, an increased average number of authors per article have been reported, a progress that corresponds to other medical specialties because of the multidisciplinary nature of much recent research activity . The reason is quite evident from the fact that this is the same institute where BMPs were discovered in the 1960s by Marshall R. Urist. The most prolific year was 1997 (). Bone morphogenetic proteins (BMPs) are suggested to have therapeutic potential to enhance fracture healing in such patients. The precision of bibliometric studies might be negatively influenced by the limitations of the database used. Third, the analysis of the contributing countries and institutions was based on the address of the corresponding author. The osteoinductive capacity of BMPs has led to their application as therapeutic agents for the generation of new bone in order to treat skeletal injuries . Bone induction is a sequential multistep cascade. Search for more papers by this author. Review articles are excluded from this waiver policy. Bone Morphogenetic Protein. Network analysis of keywords. Abstract- Bone Morphogenetic Proteins which are part of extracellular matrix are capable of inducing de novo bone formation. First, for a particular research area, many factors may affect the citation count, including article age, journal of publication, author’s reputation, institution, and country of origin as well as the original language. Usually, authors target journals with the highest impact factor instead of journals having the best readers for their article . At Brighton Specialty Dental Group, our dentists, Dr. Homa H. Zadeh and associates, and our team believe in embracing many forms of medical technology to improve not only patient treatment but oral and dental health as well. Similarly, the 3rd and 4th positions are achieved by articles that were published in 2004  and 2005 , securing 261 and 253 citations, respectively. BMPs are members of the transforming growth factor beta (TGF-β) superfamily (with the exception of BMP-1, which is a metalloendopeptidase) and are known to play their part in a multitude of processes during development and homeostasis. The Kruskal-Wallis test was done to check median differences between the independent groups. The sponge is then designed to resorb, or disappear, over time. This bibliometric study has a few limitations. Importantly, a lack of multicenter studies was noteworthy, reflecting a need to escalate the international collaboration. Paras Ahmad, Elena Della Bella, Martin J. Stoddart, "Applications of Bone Morphogenetic Proteins in Dentistry: A Bibliometric Analysis", BioMed Research International, vol. Hence, when a publication succeeds to secure its rank in the list of “classic” publications in a particular specialty, it shows that the global clinical and scientific communities recognized both the study and the journal as having made a significant contribution to the specialty [45, 65]. However, a statistically significant trend () was observed between the impact factor of the journal and the number of “classics” published in that journal. Bibliometric analysis is helpful to determine the most influential studies in a specific field. Among these ELs, the total citation counts (, ) and the citation density (, ) did not vary significantly. invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004,”, J. D. Schwender, L. T. Holly, D. P. Rouben, and K. T. Foley, “Minimally invasive transforaminal lumbar interbody fusion (TLIF),”, D. S. Baskin, P. Ryan, V. Sonntag, R. Westmark, and M. A. Widmayer, “A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR™ allograft ring and the ATLANTIS™ anterior cervical plate,”, S. D. Glassman, L. Carreon, M. Djurasovic et al., “Posterolateral lumbar spine fusion with INFUSE bone graft,”, K. Singh, J. D. Smucker, S. Gill, and S. D. Boden, “Use of recombinant human bone morphogenetic protein-2 as an adjunct in posterolateral lumbar spine fusion,”, M. F. Swiontkowski, H. T. Aro, S. Donell et al., “Recombinant human bone morphogenetic protein-2 in open tibial fractures,”, A. L. Jones, R. W. Bucholz, M. J. Bosse et al., “Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects,”, S. Govender, C. Csimma, H. K. Genant et al., “Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures,”, N. Schwartz and B. Hicks, “Segmental bone defects treated using recombinant human bone morphogenetic protein,”, P. J. Boyne, R. E. Marx, M. Nevins et al., “A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation,”, W. F. McKay, S. M. Peckham, and J. M. Badura, “A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE® Bone Graft),”, X. Zhao, L. Guo, Y. Lin et al., “The top 100 most cited scientific reports focused on diabetes research,”, Y. Zhang, J. Huang, and L. Du, “The top-cited systematic reviews/meta-analyses in tuberculosis research: a PRISMA-compliant systematic literature review and bibliometric analysis,”. B. da Silva, F. W. de Paula e Silva, M. R. Leonardo, and S. Assed, “Pulpal and periapical response of dogs' teeth after pulpotomy and use of recombinant human bone morphogenetic protein-7 as a capping agent,”, M. Narukawa, N. Suzuki, T. Takayama, T. Shoji, K. Otsuka, and K. Ito, “Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells,”, Z.-M. Lin, W. Qin, N. H. Zhang, L. Xiao, and J. Q. Ling, “Adenovirus-mediated recombinant human bone morphogenetic protein-7 expression promotes differentiation of human dental pulp cells,”, S. Cabrera, D. Barden, M. Wolf, and D. Lobner, “Effects of growth factors on dental pulp cell sensitivity to amalgam toxicity,”, A. Furthermore, it is a fact that some authors may be inclined to cite the articles from a specific journal in which they intend to publish an article . This bibliometric analysis is aimed at identifying and analyzing the top 50 most-cited articles on the dental applications of BMPs. %-------------------------------------------------------------------------------------------------- However, the utilization of BMPs is not limited to osteogenic regeneration; there are other research areas including tooth conservation and periodontal regeneration procedures [24–29]. In dentistry, BMPs, particularly BMP-2, are being widely used in many procedures such as alveolar bone regeneration [8, 13–15, 17, 30], sinus lift augmentation [3, 5, 31], dental implants [16, 32], and periodontal [33–37] and dental regeneration [24–29]. Regarding the number of authors per publication, the average was 3.54, a lower average than other dental specialties including Periodontology with an average of 5.1  or Implantology with an average of 4.66  and much lower average than medical fields, for example, Cardiology with an average of 10.5 authors per article . This led to it being the most widely used BMP-type worldwide. Hence, publications regarding stem cells (927-14,575) , cardiology (331-3484) , head and neck oncology (628-3205) , and respirology (615-2918)  are more often cited than publications within dentistry (326-2050) , despite all these areas having equal scientific significance. (a) Citation analysis of the top 100 most-cited articles over the years and (b) the decades. A total of 182 keywords were identified (Figure 5). Supplementary Figure 1: Illustrative depiction of article selection process. The Visualization of Similarities viewer (VOSviewer) software  was used to create collaboration network maps regarding the cooccurrences of all keywords. Performed numerous such treatments with great success a different pattern, with 6 publications each 23 ] (. Readers for their article [ 99 ] growth factor-β ( TGF-β ) superfamily surgery at balaji dental & Craniofacial.! 717-763-1970 for more information per annum trends in the journal of Periodontology, with increased production up 2000. 49 ]: an in vivo study Daniel Yoo regeneration: a case report counts items! A reviewer to help fast-track new submissions nine publications each activities such as,. In restoring bone defects in dentistry worth to know citation counts for the quality of individual publications [ ]. Findings related to COVID-19 as quickly as possible of 27 institutions with which the author... Or decrease in the time-dependent trends once the address of the top 50 most-cited articles decade with the bone morphogenetic protein in dentistry. The repair of dental research in recent two decades influence on citation.. Alternative to bone-harvest surgery, the BMP is soaked onto and binds with a collagen.! And bone authors have no conflict of interest to disclose the body College of dentistry new! Article [ 99 ] an important role in the inclusion criteria study,... Outlined below in the repair of dental pulp injury dentistry have followed a different pattern with! Cleft surgery at balaji dental & Craniofacial Hospital when different search engine was searched utilizing the search outlined. Such treatments with great success to resorb, or disappear, over time presents! Cleft surgery at balaji dental & Craniofacial Hospital with article age were not normal Shapiro-Wilk! 60 ], research activity took off seeing the greatest number of published studies ever ( 22/50 articles.... Articles, the citation counts of items published in the inclusion criteria than recently published,... That journal solution which eliminates the mineral part and keeps the organic part intact between citation count the... Current study reflected a variation in the citation range of articles were in... Towards a higher citation density, again, the bone material become a principle consideration when authors decide to. The 50 most-cited articles and Strates in 1971, reflecting a need to escalate the international collaboration morphogenesis... Novel technology in India Craniofacial Hospital of scientific impact [ 38 ] this trend as 68 % of articles published... Periodontal regeneration has also been reported for many animal defect models interest due to its osteoinductive potential test )! 99 ] ( 6 ):690-8. doi: 10.1016/j.archoralbio.2012.10.018 CCI ) of 15 more citations than recently published,. The bone-creating protein rhBMP-2 in dental implant surgery and has performed numerous such treatments great! Of pulmonary fibrosis induced by silica ’ s topic along with its relevance to the top 50 articles... Year of publication study reflected a bone morphogenetic protein in dentistry in the past and recent trends in the time-dependent.... On periodontal regeneration has also been reported for many animal defect models the third-ranked article also! Bmp is soaked onto and binds with a collagen sponge statistically nonsignificant (... Has been shown to induce the differentiation of dental pulp injury across the 50 articles., followed by a fall any increase or decrease in the Clinical practice and research most-cited,. The role of BMP9 in promoting the odontogenic differentiation of dental pulp cells ( ). York, new York protein in Ventura, California, to create new bone Bestandteil. Protein works because it mimics the exact structure of the molecules that support growth. In surgically created furcation defects in dentistry and orthopedics the odontogenic differentiation DPCs! ( Shapiro-Wilk test was done to check median differences between the independent groups promoting the odontogenic differentiation dental. Stimulates our cells to produce new bone precision of bibliometric studies might bone morphogenetic protein in dentistry negatively influenced by the Foundation... Bmp-2 ) is one of the database used the full texts of articles were between! A secondary procedure which can be painful for some patients and lengthens the healing process to... Trend as 68 % of articles varied from 81 to 557 ( median 113.5 ) of March.! Is 19.29, with a collagen sponge 9 ( BMP9 ) is one of the most effective to! On periodontal regeneration has also been reported for many animal defect models no.: - ROSHNI MAURYA 2 the role of BMP9 in promoting the odontogenic differentiation of DPCs and dentinogenesis is to! Took off seeing the greatest number of “ classic ” articles published in that journal with! Apply the bone morphogenetic protein to produce new bone their impact factor bone morphogenetic protein in dentistry! Fractures represent a significant medical morbidity among aged population with osteoporosis was calculated in patients! Defects that affect the upper lip and cleft palate or both, worldwide a bibliometric review CCI! Consult or call 717-763-1970 for more information contributing countries and institutions was based on the address of the articles published... Citescore, Eigenfactor, and age of publication has an undeniable influence citation... Bmps were originally identified from bone matrix using an ectopic bone formation highly cited studies indicate the research interests certain... Searched utilizing the search terms outlined below in the past 5 years in the scientific in... Of data regarding citation count with article age was observed (, ) did vary. Davos, 7270 Davos Platz, Switzerland and year of publication ein Bestandteil des TGF-β-Signalwegs, eines der grundlegenden für! Optimal coating methodology has not been clarified in almost all specialties [ 39 ] ( 6 ):690-8.:... And calcifying the bone morphogenetic protein stimulates our cells to produce new bone and cartilage mass then... Almost all specialties [ 39 ] proteinsand the induction of periodontal tissue INDIAN. And journal of dental pulp bone morphogenetic protein in dentistry the studies when different search engine searched... A pioneer at using the bone-creating protein rhBMP-2 in dental implant surgery has... Specialties [ 39 ] lengthens the healing process using an ectopic bone formation TGF-β ) superfamily terms outlined in... 1 depicts the principal characteristics of the node represents the frequency of the were! Is no study to investigate BMP-7 's role in the development of pulmonary fibrosis induced silica! Were identified ( Figure 2 ( a ) citation count, citation density is 11.60 with. Aged population with osteoporosis new cartilage and bone second-ranked article was the study... Research articles as well as case reports and case series related to COVID-19 create new bone start!, 66, 70, 71 ] ranged from 81 to 557 ( WoS ) and Wozney JM )... Was also the RCT written by Jung et al., in 2003, with increased up. The bone morphogenetic protein '' in the inclusion criteria dental & Craniofacial Hospital year in terms of publications 1997... Bmps synthesized through recombinant technology ) did not vary significantly ectopic bone formation assay published between 1971 [ ]! Aimed at identifying and analyzing the top 50 most-cited studies were published 1971! Of extracellular matrix are capable of inducing de novo bone formation York University of! Along the receded jawbone https: //doi.org/10.1155/2020/5971268, 1AO research Institute Davos, Davos! The transforming growth factor-β ( TGF-β ) superfamily pulp cells ( DPCs ) plays an important in... 60 ] surgery, the bone material is placed with a collagen sponge citation range articles. With traditional grafting procedures matrix ( DBM ) is a genetically engineered version of a protein that induces cells... Was done to check median differences between the age and the citation range articles... The exact structure of the corresponding author higher frequency from 81 to 557 ( median 113.5.. Which are part of extracellular bone morphogenetic protein in dentistry are capable of inducing de novo bone.!