In theory, the acknowledgment of a research within the scientific area (citation count) and how it influenced the knowledge of a disease and/or its treatment, as well as whether it brought about any new research trends, are the reflection of its quality [64]. The authors have no conflict of interest to disclose. (1)Five-year journal impact factor: this indicator represents the citation counts received by a journal, in one year, of the citable papers published in the last 5 years. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone.During surgery, the BMP is soaked onto and binds with a collagen sponge. The key steps in this cascade are chemotaxis, mitosis, and differentiation. Sign up here as a reviewer to help fast-track new submissions. UCLA Bone Research Laboratory, Department of Surgery, School of Medicine, University of California, Los Angeles, California 90024, USA ... Journal of Dental Research ISSN: 0022-0345 Online ISSN: 1544-0591. In the present study, majority of the studies (58%) were published in high impact factor journals dedicated to dentistry, oral surgery, and medicine such as the Journal of Periodontology, Journal of Dental Research, Journal of Clinical Periodontology, and Clinical Oral Implants Research. The bone morphogenetic family and osteogenesis. Dental implants anchor the permanent prosthetic teeth to the bone. >> T1 - The application of bone morphogenetic proteins to dental tissue engineering. The differentiation of dental pulp cells (DPCs) plays an important role in the repair of dental pulp injury. Recombinant human BMP‐2 (rhBMP‐2), for example, has been shown to induce ectopic bone formation in an in vivo setting. The journals’ ranking based on their impact factor has become a principle consideration when authors decide where to submit their research. Several bibliometric studies have reported that authors hailing from institutions of Asia and Africa whether being the first or the corresponding authors made an almost negligible contribution which could be regarded as the “classic article” [76, 83, 88, 90, 91]. Second, the analysis of self-citations and citations in textbooks and lectures was not performed. Bone Morphogenetic Protein. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. This bibliometric analysis is aimed at identifying and analyzing the top 50 most-cited articles on the dental applications of BMPs. Its calculation follows the following formula: citations from journal citation report (JCR) year of documents published in the last 5 years, divided by the total number of citable documents [56]. Bibliometric analysis is helpful to determine the most influential studies in a specific field. /ToUnicode 6 0 R The top 50 most-cited publications originated from 11 countries, including Austria, Brazil, Germany, Italy, Japan, Netherlands, South Africa, South Korea, Switzerland, the United Kingdom (UK), and the United States of America (USA) (Figure 4(a)). The sponge is then designed to resorb, or disappear, over time. BMP-2, BMP-4, and BMP-7 have been reported to stimulate in vivo, in vitro, and de novo bone formation in several animal models [13, 14, 16, 18]. Bone morphogentic protein 1. Introduction. As the sponge dissolves, the bone morphogenetic protein stimulates the cells to produce new bone. However, in the recent years, an increased average number of authors per article have been reported, a progress that corresponds to other medical specialties because of the multidisciplinary nature of much recent research activity [82]. The reason is quite evident from the fact that this is the same institute where BMPs were discovered in the 1960s by Marshall R. Urist. The most prolific year was 1997 (). Bone morphogenetic proteins (BMPs) are suggested to have therapeutic potential to enhance fracture healing in such patients. The precision of bibliometric studies might be negatively influenced by the limitations of the database used. Third, the analysis of the contributing countries and institutions was based on the address of the corresponding author. The osteoinductive capacity of BMPs has led to their application as therapeutic agents for the generation of new bone in order to treat skeletal injuries [19]. Bone induction is a sequential multistep cascade. Search for more papers by this author. Review articles are excluded from this waiver policy. Bone Morphogenetic Protein. Network analysis of keywords. Abstract- Bone Morphogenetic Proteins which are part of extracellular matrix are capable of inducing de novo bone formation. First, for a particular research area, many factors may affect the citation count, including article age, journal of publication, author’s reputation, institution, and country of origin as well as the original language. Usually, authors target journals with the highest impact factor instead of journals having the best readers for their article [99]. At Brighton Specialty Dental Group, our dentists, Dr. Homa H. Zadeh and associates, and our team believe in embracing many forms of medical technology to improve not only patient treatment but oral and dental health as well. Similarly, the 3rd and 4th positions are achieved by articles that were published in 2004 [59] and 2005 [61], securing 261 and 253 citations, respectively. BMPs are members of the transforming growth factor beta (TGF-β) superfamily (with the exception of BMP-1, which is a metalloendopeptidase) and are known to play their part in a multitude of processes during development and homeostasis. The Kruskal-Wallis test was done to check median differences between the independent groups. The sponge is then designed to resorb, or disappear, over time. This bibliometric study has a few limitations. Importantly, a lack of multicenter studies was noteworthy, reflecting a need to escalate the international collaboration. Paras Ahmad, Elena Della Bella, Martin J. Stoddart, "Applications of Bone Morphogenetic Proteins in Dentistry: A Bibliometric Analysis", BioMed Research International, vol. Hence, when a publication succeeds to secure its rank in the list of “classic” publications in a particular specialty, it shows that the global clinical and scientific communities recognized both the study and the journal as having made a significant contribution to the specialty [45, 65]. However, a statistically significant trend () was observed between the impact factor of the journal and the number of “classics” published in that journal. Bibliometric analysis is helpful to determine the most influential studies in a specific field. Among these ELs, the total citation counts (, ) and the citation density (, ) did not vary significantly. invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004,”, J. D. Schwender, L. T. Holly, D. P. Rouben, and K. T. Foley, “Minimally invasive transforaminal lumbar interbody fusion (TLIF),”, D. S. Baskin, P. Ryan, V. Sonntag, R. Westmark, and M. A. Widmayer, “A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR™ allograft ring and the ATLANTIS™ anterior cervical plate,”, S. D. Glassman, L. Carreon, M. Djurasovic et al., “Posterolateral lumbar spine fusion with INFUSE bone graft,”, K. Singh, J. D. Smucker, S. Gill, and S. D. Boden, “Use of recombinant human bone morphogenetic protein-2 as an adjunct in posterolateral lumbar spine fusion,”, M. F. Swiontkowski, H. T. Aro, S. Donell et al., “Recombinant human bone morphogenetic protein-2 in open tibial fractures,”, A. L. Jones, R. W. Bucholz, M. J. Bosse et al., “Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects,”, S. Govender, C. Csimma, H. K. Genant et al., “Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures,”, N. Schwartz and B. Hicks, “Segmental bone defects treated using recombinant human bone morphogenetic protein,”, P. J. Boyne, R. E. Marx, M. Nevins et al., “A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation,”, W. F. McKay, S. M. Peckham, and J. M. Badura, “A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE® Bone Graft),”, X. Zhao, L. Guo, Y. Lin et al., “The top 100 most cited scientific reports focused on diabetes research,”, Y. Zhang, J. Huang, and L. Du, “The top-cited systematic reviews/meta-analyses in tuberculosis research: a PRISMA-compliant systematic literature review and bibliometric analysis,”. B. da Silva, F. W. de Paula e Silva, M. R. Leonardo, and S. Assed, “Pulpal and periapical response of dogs' teeth after pulpotomy and use of recombinant human bone morphogenetic protein-7 as a capping agent,”, M. Narukawa, N. Suzuki, T. Takayama, T. Shoji, K. Otsuka, and K. Ito, “Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells,”, Z.-M. Lin, W. Qin, N. H. Zhang, L. Xiao, and J. Q. Ling, “Adenovirus-mediated recombinant human bone morphogenetic protein-7 expression promotes differentiation of human dental pulp cells,”, S. Cabrera, D. Barden, M. Wolf, and D. Lobner, “Effects of growth factors on dental pulp cell sensitivity to amalgam toxicity,”, A. Furthermore, it is a fact that some authors may be inclined to cite the articles from a specific journal in which they intend to publish an article [115]. This bibliometric analysis is aimed at identifying and analyzing the top 50 most-cited articles on the dental applications of BMPs. %-------------------------------------------------------------------------------------------------- However, the utilization of BMPs is not limited to osteogenic regeneration; there are other research areas including tooth conservation and periodontal regeneration procedures [24–29]. In dentistry, BMPs, particularly BMP-2, are being widely used in many procedures such as alveolar bone regeneration [8, 13–15, 17, 30], sinus lift augmentation [3, 5, 31], dental implants [16, 32], and periodontal [33–37] and dental regeneration [24–29]. Regarding the number of authors per publication, the average was 3.54, a lower average than other dental specialties including Periodontology with an average of 5.1 [79] or Implantology with an average of 4.66 [80] and much lower average than medical fields, for example, Cardiology with an average of 10.5 authors per article [81]. This led to it being the most widely used BMP-type worldwide. Hence, publications regarding stem cells (927-14,575) [72], cardiology (331-3484) [73], head and neck oncology (628-3205) [74], and respirology (615-2918) [75] are more often cited than publications within dentistry (326-2050) [44], despite all these areas having equal scientific significance. 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